Human Chromosome 7: DNA Sequence and Biology

Statistical analysis of the DNA sequence of human chromosome 22.

We study statistical patterns in the DNA sequence of human chromosome 22, the first completely sequenced human chromosome. We find that (i). the 33.4 x 10(6) nucleotide long human chromosome exhibits long-range power-law correlations over more than four orders of magnitude, (ii). the entropies H(n) of the frequency distribution of oligonucleotides of length n (n-mers) grow sublinearly with incr...

The DNA sequence of human chromosome 21 The chromosome 21 mapping and sequencing consortium

The chromosome 21 mapping and sequencing consortium M. Hattori*, A. Fujiyama*, T. D. Taylor*, H. Watanabe*, T. Yada*, H.-S. Park*, A. Toyoda*, K. Ishii*, Y. Totoki*, D.-K. Choi*, E. Soeda2, M. Ohki3, T. Takagi§, Y. Sakaki*§; S. Taudienk, K. Blechschmidtk, A. Polleyk, U. Menzelk, J. Delabar¶, K. Kumpfk, R. Lehmannk, D. Patterson#, K. Reichwaldk, A. Rumpk, M. Schillhabelk, A. Schudyk, W. Zimmerma...

Identification of Human Chromosome Segments that Have High Homology with Rat Genomic DNA

This study was conducted to determine the location of DNA segment with homology to the rat conserved genomic DNA in human chromosomes. The labeled rat genomic DNA was hybridized with normal human (male) metaphases. The study of 74 metaphases after fluorescence in situ hybridization showed 371 twin-spot signals on human chromosomes. Statistical analysis indicated that the specific accumulation o...

Maternal Uniparental Disomy of Human Chromosome 7

DNA sequence and comparative analysis of chimpanzee chromosome 22.

Human-chimpanzee comparative genome research is essential for narrowing down genetic changes involved in the acquisition of unique human features, such as highly developed cognitive functions, bipedalism or the use of complex language. Here, we report the high-quality DNA sequence of 33.3 megabases of chimpanzee chromosome 22. By comparing the whole sequence with the human counterpart, chromoso...